I have both MTHFR mutations which has wrecked my health. After research, I learned that I need a certain type of B vitamins (these) as well as trimethylglycine (hard to find.) Dr. Myers of course put the best of everything in here. I’ve read that for people like me who haven’t been methylating properly, it’s best not to take full doses of methyl Bs at once, to ease into it... which makes sense to me because at first when I started taking it, my eyes were twitching. I’m still only taking one capsule every other day, and I think I can go to one capsule a day soon, and so on. After I take it, it’s like all the cells in my body feel quenched. Hard to explain, but I know it’s so good for me. So needed. I only wish the price point were more affordable so more people could reap the benefits.