I believe I have leaky gut that has lead to autoimmune issues. My Dr. is useless so I've been healing myself with Amy Myers protocol as much as I can and using a LOT of her different products. It's hard to say that it's just the complete enzymes that are helping or any one of the other products I'm throwing at my issues. I do know it's hard to figure out what product you actually need because they all seem to say the same thing, just in different words. I took one star away because as I found an empty capsule in my bottle.